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Neuralisse Side Effects: What Each Ingredient Can Do and Which Medicines Clash
Most reported side effects of the Neuralisse ingredients are mild: stomach upset, nausea, diarrhea or trouble sleeping. The bigger risks are interactions. Alpha-lipoic acid can lower blood sugar, turmeric and coenzyme Q10 may add to blood thinners, and magnesium must be spaced from some antibiotics and bone drugs. Ask a doctor first if you take any medicine.
Written by the Neuralisse editorial teamUpdated
The short version
Does Neuralisse have side effects?
Yes, it can. Every active ingredient in Neuralisse has reported side effects, though most are mild and affect the stomach or sleep.
No study has tested Neuralisse itself, so nobody knows how often its users get side effects. Instead, we look at each of the six ingredients using NIH, Memorial Sloan Kettering (MSKCC) and LiverTox sources.
The label carries its own warning, word for word: "Do not exceed recommended dose. Not for use for those under the age of 18 or pregnant or nursing mothers. Consult with a physician prior to use especially if you are taking a medication or have a medical condition."
A product called "natural" is not automatically safe, and supplements can interact with prescription drugs (ODS, What you need to know).
Ingredient by ingredient
What side effects can each Neuralisse ingredient cause?
Stomach complaints are the common thread. A few ingredients carry rarer, more serious warnings.
| Ingredient | Per capsule | Common side effects | Rare or serious |
|---|---|---|---|
| Magnesium glycinate | 80 mg magnesium | Diarrhea, nausea, cramps at high supplement doses (ODS, Magnesium) | Buildup in people with kidney problems (ODS, Magnesium (HP)) |
| Alpha-lipoic acid | At most 287 mg | Nausea (MSKCC, Alpha-lipoic acid) | Low blood sugar; rare insulin autoimmune syndrome (MSKCC, Alpha-lipoic acid) |
| Butcher's broom | At most 191 mg | Diarrhea, itchy skin (MSKCC, Butcher's broom) | A reported case of ketoacidosis in a person with diabetes (MSKCC, Butcher's broom) |
| L-carnitine | At most 143 mg | Nausea, cramps, diarrhea, fishy body odor at about 3 g a day (ODS, Carnitine (HP)) | Open questions about TMAO, a gut byproduct (ODS, Carnitine (HP)) |
| Turmeric extract | At most 115 mg | None listed in our sources | Liver injury (very rare); kidney stones; bleeding (LiverTox, Turmeric) (MSKCC, Turmeric) |
| Coenzyme Q10 | At most 95 mg | Trouble sleeping, upset stomach, nausea, diarrhea (NCCIH, CoQ10) (MSKCC, CoQ10) | No serious side effects reported in studies (NCCIH, CoQ10) |
The L-carnitine side effects above were seen at about 3 grams a day, far more than the 143 mg ceiling in one capsule. Magnesium side effects also tend to appear well above 80 mg.
Medicines
Which medicines interact with Neuralisse?
Diabetes drugs, blood thinners, some antibiotics, bone drugs and seizure medicines top the list. Bring this table and your medicine list to a pharmacist before your first capsule.
| Medicine type | Examples | Ingredient involved | What may happen |
|---|---|---|---|
| Diabetes medicines | Insulin, metformin, sulfonylureas | Alpha-lipoic acid; coenzyme Q10 | Blood sugar may drop lower than expected (MSKCC, Alpha-lipoic acid); CoQ10 may interact with insulin (NCCIH, CoQ10) |
| Blood thinners | Warfarin and similar drugs | Turmeric; coenzyme Q10 | Higher bleeding risk or a change in warfarin effect (MSKCC, Turmeric) (MSKCC, CoQ10) |
| Bisphosphonates | Alendronate and other oral bone drugs | Magnesium | Less of the drug absorbed; keep them 2 hours apart (ODS, Magnesium (HP)) |
| Tetracycline and quinolone antibiotics | Doxycycline, ciprofloxacin | Magnesium | Less antibiotic absorbed; take the antibiotic 2 hours before or 4-6 hours after (ODS, Magnesium (HP)) |
| Diuretics and long-term PPIs | Water pills, acid reducers | Magnesium | Can change the body's magnesium level (ODS, Magnesium (HP)) |
| Some seizure medicines | Ask your pharmacist which ones | L-carnitine | These drugs can lower carnitine levels (ODS, Carnitine (HP)) |
| Statins | Cholesterol medicines | Coenzyme Q10 | Statins lower the body's own CoQ10 (MSKCC, CoQ10) |
| Many prescription drugs | Drugs processed by the liver | Turmeric | Turmeric affects drug-processing enzymes (MSKCC, Turmeric) |
Never stop or change a prescription to make room for a supplement.
Diabetes
Can people with diabetes take Neuralisse?
Only after talking with their doctor, and two ingredients are the reason. Alpha-lipoic acid can lower blood sugar and may add to the effect of diabetes medicines (MSKCC, Alpha-lipoic acid). MSKCC lists diabetes as a reason not to take butcher's broom, after a report of ketoacidosis (MSKCC, Butcher's broom).
That second point matters, because many people shopping for nerve support have diabetes. NCCIH advises never replacing diabetes care with an unproven product (NCCIH, Diabetes and supplements). Keeping blood sugar near your goal is what helps keep nerve problems from getting worse (NIDDK, Peripheral neuropathy).
Ask your care team before starting. If they agree, check your blood sugar more often for the first weeks and watch for shakiness, sweating or confusion.
Not for everyone
Who should not take Neuralisse?
The label rules out three groups outright; several more need a doctor's approval.
Do not take it
- Anyone under 18
- Pregnant women
- Nursing mothers
Ask before taking it
- People with diabetes
- Blood thinner users
- Kidney or liver disease
- Anyone on bisphosphonates, antibiotics or seizure medicines
- Anyone with surgery planned (ODS, What you need to know)
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Can Neuralisse affect the liver?
The risk is low but not zero, and turmeric is the ingredient to watch. LiverTox calls turmeric the leading herbal cause of liver injury in the U.S., while noting it is very rare (LiverTox, Turmeric). NCCIH links most cases to forms built to absorb better (NCCIH, Turmeric).
The other ingredients look reassuring on this point. LiverTox rates alpha-lipoic acid (LiverTox, Alpha lipoic acid) and coenzyme Q10 (LiverTox, CoQ10) as unlikely causes of liver injury.
Act fast
When should you stop Neuralisse and call a doctor?
Stop and call right away at any sign of a serious reaction. Go to an emergency room or call 911 for trouble breathing or swelling of the face or throat.
Liver warning signs
Yellow skin or eyes, dark urine, pale stools, itching, or tiredness that will not lift.
Low blood sugar
Shakiness, sweating, fast heartbeat, confusion or sudden hunger, especially if you use diabetes medicine.
Bleeding signs
Unusual bruising, nosebleeds, bleeding gums, or blood in urine or stool.
Ongoing diarrhea or a lasting rash also means stop and call. New or worsening numbness, tingling, weakness or a foot sore needs medical care whether or not you take a supplement (CDC, Diabetes and your feet).
Report it
How do you report a side effect from Neuralisse?
Tell your doctor first, then report it to FDA's MedWatch program. MedWatch collects reports of problems with supplements as well as drugs, and you do not need a doctor to file one.
- Keep the bottle, the label and any capsules left.
- Write down when you started and when symptoms began.
- Note every medicine and supplement you take.
- Call the order desk at +1 (302) 200-3480 for your order details, or to return bottles within the 60-day window.
Bottom line
Is Neuralisse safe?
For many healthy adults on few medicines, its ingredients have a mild side effect profile. For people with diabetes, blood thinner users and anyone with kidney or liver disease, it needs a doctor's yes first.
FAQ
Neuralisse side effects: questions people ask
What are the side effects of Neuralisse?
The most likely side effects are mild: upset stomach, nausea, diarrhea or trouble sleeping. These come from the ingredient research, since Neuralisse itself has not been studied. Rarer risks include low blood sugar from alpha-lipoic acid, bleeding with blood thinners and, very rarely, liver injury from turmeric.
Can I take Neuralisse with metformin?
Ask your doctor first. Alpha-lipoic acid can lower blood sugar and may add to diabetes medicines like metformin. MSKCC also lists diabetes as a reason not to take butcher's broom. If your doctor agrees, check your blood sugar more often during the first weeks.
Can I take Neuralisse with blood thinners?
Not without your doctor's approval. Turmeric can raise bleeding risk and is not advised with warfarin, according to MSKCC. Coenzyme Q10 may also interact with warfarin. With two such ingredients in one capsule, a pharmacist should review your full medicine list.
Does Neuralisse cause diarrhea?
It might for some people. Magnesium, butcher's broom, L-carnitine and coenzyme Q10 all list diarrhea as a possible side effect. If loose stools last more than a few days, stop and call your doctor.
Is Neuralisse safe for kidneys?
People with kidney disease should ask a doctor first. The NIH notes that magnesium toxicity risk rises when the kidneys do not work well. MSKCC also says turmeric may raise the risk of kidney stones.
Can Neuralisse lower blood sugar?
One ingredient can. Alpha-lipoic acid may lower blood sugar, and the effect may add to diabetes medicines. Neuralisse is not a blood sugar treatment and should never replace diabetes care. Watch for shakiness, sweating or confusion, and treat low blood sugar as your care plan says.
How do I report a bad reaction to a supplement?
Call your doctor, then file a report with FDA's MedWatch program, which accepts reports from consumers. Keep the bottle and note the dates and symptoms. For a refund or return of Neuralisse, call the order desk at +1 (302) 200-3480 with your order ID.
Who wrote this
Written and reviewed by
Plain-language pages built from the bottle label, the order page and linked public health sources such as NIH, FDA and CDC.
Last updated . Read our editorial standards and how we check reviews. This website is run by an American stocking outlet for Neuralisse, not by the manufacturer. We earn money when you buy through our order links.
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